Clinical Studies Examining Thrombosis Related to Autoimmune Antiphospholipid Antibodies
نویسندگان
چکیده
Laboratory diagnosis of APS relies on the demonstration of positive antiphospholipid antibodies (aPL), including anticardiolipin antibody (aCL) and/or anti2 glycoprotein I antibody (anti2GPI) by an in-house or commercially available enzyme-linked immunosorbent assay (ELISA) or lupus anticoagulant (LA) by a coagulation-based test. The relationship between aPL and thrombosis has been abundantly studied. However, the reported results, largely influenced by differences in study design, patient population and antibody assays, have been controversial and the precise serological ‘fingerprint’ of the patients most at risk of thrombosis remains elusive.
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Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinic...
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